Results: Both SARS-CoV-2 and Lenti-Spike stimulated strong inflammatory responses by inducing the expression of key cytokine and chemokines, including IL-1β, IL-6, TNFα, CCL-2, and CXCL-10, in murine and human macrophages in vitro, whereas Lipo-hACE2 decoy abolished these effects in macrophages. Liposome-hACE2 was used as a decoy receptor or competitive inhibitor to inhibit SARS-CoV-2 or Lenti-Spike-induced macrophage inflammation in vitro and in vivo. Lentivirus expressing Spike protein (D614G) was also created as a pseudo-SARS-CoV-2 (Lenti-Spike). Methods: hACE2 was biotinylated to the surface of nano-liposomes (d = 100 nm) to generate Liposome-human ACE2 complex (Lipo-hACE2). This study aims to investigate whether an engineered decoy receptor can abrogate SARS-CoV-2-induced macrophage inflammation. Neutralizing SARS-CoV-2 by human ACE2 (hACE2) decoys has been proposed as a therapeutic approach to ameliorate SARS-CoV-2-stimulated inflammation. However, the mechanisms underlying SARS-CoV-2-elicited macrophage inflammatory responses remain elusive. Angiotensin-converting enzyme 2 (ACE2) serves as the binding receptor to SARS-CoV-2 Spike glycoprotein for fusion and internalization into the human host cells. You can detox from spike protein by staying hydrated, eating a healthy diet, getting plenty of rest, considering supplements, and seeking professional help.īook an appointment with Nao Medical today to learn more about how we can help you detox from spike protein and improve your overall health.Rationale: Macrophages are the frontline immune cells in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Spike protein accumulation can cause a range of health issues, including inflammation, blood clotting, and damage to the cardiovascular system. What are the health risks associated with spike protein accumulation? Spike protein is a protein that is produced by the COVID-19 virus and is essential for the virus to enter human cells. Book an appointment with us today to learn more about how we can help you detox from spike protein and improve your overall health. At Nao Medical, we offer a range of services to help you detox and improve your overall health, including urgent care, primary care, multi-speciality care, mental health, women’s health, nutrition services, and more. If you’re concerned about spike protein accumulation in your body, it’s essential to seek professional help. Talk to your healthcare provider before starting any new supplements to ensure they are safe and effective for you. There are several supplements that can help support your body’s natural detoxification processes, including milk thistle, N-acetyl cysteine, and glutathione. Aim for at least seven to eight hours of sleep per night, and try to establish a regular sleep schedule to help your body get into a rhythm. Your body does most of its detoxing while you sleep, so it’s essential to get plenty of rest. Avoid processed foods, sugary drinks, and alcohol, which can all contribute to inflammation and make it harder for your body to detox. Tip #2: Eat a Healthy DietĮating a diet rich in fruits, vegetables, and whole grains can help support your body’s natural detoxification processes. Aim to drink at least eight glasses of water per day, and consider adding lemon or lime juice to your water for an extra detox boost. Tip #1: Stay Hydratedĭrinking plenty of water is essential for flushing toxins out of your body, including spike protein. Our team of healthcare professionals has put together some tips to help you detox and improve your overall health. While the spike protein is essential for the virus to enter human cells, it can also cause a range of health issues when it accumulates in the body.Īt Nao Medical, we understand the importance of detoxing from spike protein after COVID or vaccine. As the world continues to grapple with the COVID-19 pandemic, many people are concerned about the spike protein that is produced by the virus and the vaccines that have been developed to combat it.
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